50. Correct. The answer is false. In general, integration by substitution is performed as follows: f(x)dx = u(du/dx)dx = udu = F(u) +c. Therefore, set u=x3+1, then du/dx = 3x2 and dx = du/3x2. Substitute this into the integrand: 16x2(x3+1)dx = 15x2*udu/3x2 = 5udu = 5*0.5u2 + c = 2.5u2 +c = 2.5(x3+1)2 + c.