50. Incorrect. The answer is false, not true. In general, integration by substitution is performed as follows: ∫f(x)dx = ∫u(du/dx)dx = ∫udu = F(u) +c. Therefore, set u=x3+1, then du/dx = 3x2 and dx = du/3x2. Substitute this into the integrand: ∫16x2(x3+1)dx = ∫15x2*udu/3x2 = ∫5udu = 5*0.5u2 + c = 2.5u2 +c = 2.5(x3+1)2 + c.